Adolescent reproductive health education in schools is crucial for promoting healthy behaviors and reducing risky practices among youth. In Ghanaian cities, school-based health education programmes are implemented to address these issues. However, their effectiveness varies, necessitating a comprehensive evaluation. A mixed-methods approach will be utilised, incorporating surveys with Likert scales (e.g., $Y = \beta_0 + \beta_1X + \epsilon$) to measure students' perceptions of health education programmes and their effects on knowledge and attitudes towards reproductive health. Response rates are expected to reach at least 85%. In this preliminary study, a direction for student response themes regarding programme effectiveness was identified (e.g., 'engagement level' with an observed proportion of 70%). This research aims to provide insights into the efficacy of school-based health education programmes in Ghanaian cities by leveraging findings from Botswana schools. Future studies should consider expanding the sample size and exploring additional variables such as parental involvement and community support.