The business environment in Ghana is characterised by significant structural constraints, including infrastructural deficits, regulatory complexities, and access to finance. While strategic adaptation is recognised as critical for enterprise survival and growth, there is a paucity of large-scale, longitudinal survey data examining how firms navigate these challenges over time. This study aims to systematically analyse the primary structural constraints faced by enterprises and document their evolving strategic adaptation responses. It seeks to identify the most salient barriers to business operations and quantify the prevalence of specific adaptive strategies employed. A stratified random sample of 850 registered enterprises across sectors and sizes participated in a structured survey. The instrument measured perceived constraint severity, strategic actions undertaken, and firm performance indicators. Quantitative data were analysed using descriptive and inferential statistics. Access to long-term capital was identified as the most severe constraint, cited by 78% of respondents. A dominant adaptive strategy was supply chain localisation, with 65% of firms reporting a deliberate shift towards local suppliers to mitigate currency and import volatility. A significant positive correlation was found between the diversity of adaptation strategies and reported revenue stability. Structural constraints remain deeply embedded, compelling enterprises to develop sophisticated, locally-oriented adaptive strategies. The capacity to adapt is not uniform, with smaller firms demonstrating greater strategic agility but facing higher resource limitations in implementation. Policy should prioritise deepening domestic capital markets and de-risking lending to small and medium-sized enterprises. Business development programmes must move beyond generic training to facilitate firm-specific strategic adaptation planning. Further research should track the longitudinal performance outcomes of different adaptive archetypes. Strategic adaptation, structural constraints, business environment, enterprise survey, Ghana, behavioural finance This paper provides a novel, longitudinal dataset tracking firm-level strategic responses to systemic constraints, offering a behavioural lens on corporate decision-making under persistent adversity.