The Nigerian business environment is characterised by persistent structural constraints, including infrastructure deficits, regulatory complexity, and limited access to finance. These constraints have historically stifled enterprise resilience and growth, necessitating a coherent policy response that moves beyond isolated interventions. This policy brief aims to synthesise evidence on the most binding constraints to enterprise development and to propose a novel, integrated policy framework designed to enhance systemic resilience and sustainable growth for businesses. The analysis employs a mixed-methods approach, integrating a systematic review of policy documents and academic literature with a thematic analysis of stakeholder interviews and focus group discussions with entrepreneurs, policymakers, and financiers. A dominant theme identified is the critical interaction between infrastructure gaps and financing costs, which collectively erode profitability for over 70% of surveyed small and medium-sized enterprises. The analysis reveals that fragmented policy measures have often failed due to a lack of coordination between monetary, fiscal, and industrial policy domains. Structural constraints are interconnected and require a systemic, rather than sectoral, policy approach. Resilience and growth are achievable only through mechanisms that simultaneously address multiple bottlenecks within the business ecosystem. Implement a coordinated 'Resilience Covenant' linking targeted infrastructure investment to de-risked credit mechanisms. Establish an independent regulatory review commission to streamline business regulations. Foster public-private dialogue platforms for continuous policy feedback and adaptation. structural constraints, enterprise resilience, policy coordination, business environment, Nigeria, growth framework This brief introduces a novel policy mechanism, the 'Resilience Covenant', which formally links fiscal infrastructure commitments to monetary sector de-risking instruments, offering a new model for integrated economic governance.