The performance of enterprises in Tanzania is significantly shaped by a complex interplay of institutional frameworks, infrastructural limitations, and market dynamics. Understanding how firms navigate these structural constraints is critical for fostering sustainable economic development, yet comprehensive longitudinal survey data capturing strategic adaptation over time remains scarce. This study aims to systematically analyse the relationship between perceived structural constraints, strategic adaptation mechanisms, and reported enterprise performance. Its objectives are to identify the most binding constraints, catalogue prevalent strategic responses, and quantify their association with key performance indicators. A stratified random sample of 450 formal and informal enterprises across five regions participated in a structured survey. The instrument measured perceptions of constraints (using a Likert scale), adaptation strategies employed, and performance metrics. Quantitative data were analysed using descriptive statistics and multivariate regression techniques. Infrastructural deficits, particularly in electricity and logistics, were cited as a severe or very severe constraint by 78% of respondents. A key finding is that firms employing proactive digital adaptation strategies, such mobile money integration, reported a statistically significant 22% higher revenue growth than those relying solely on traditional methods, even when controlling for sector and size. Enterprise performance is not merely a function of external constraints but is critically mediated by strategic choice. Proactive, technology-enabled adaptation emerges as a potent mitigator of structural impediments, highlighting the agency of firms within a challenging operational environment. Policy should prioritise investments in core physical infrastructure while concurrently fostering digital literacy and access. Enterprise support programmes must move beyond generic advice to facilitate context-specific strategic adaptation, particularly in digital tool adoption. strategic adaptation, structural constraints, enterprise performance, business environment, survey research, Tanzania This paper provides a novel, longitudinal dataset tracking enterprise strategy and performance, offering unprecedented granularity on the evolution of business constraints and adaptive responses within the Tanzanian context.