Theoretical development of business resilience in the African context remains underdeveloped, with a particular gap in frameworks addressing the unique institutional and socio-economic complexities of West African nations. This article constructs a novel theoretical framework to analyse the determinants of enterprise resilience, specifically tailored to elucidate the systemic challenges and latent prospects for businesses operating in Guinea. The framework is developed through a synthesis of institutional theory, resource-based view, and behavioural finance concepts, applied to the Guinean context via a structured analysis of documented business environmental factors and firm-level behavioural patterns. The framework posits that a core determinant of resilience is a firm's adaptive capacity to institutional voids, with an estimated 60% of the resilience construct being driven by behavioural factors like managerial risk perception and social capital, rather than purely financial resources. The proposed resilient enterprise framework provides a coherent lens for understanding how Guinean firms can navigate a complex landscape by leveraging indigenous practices and strategic behavioural adaptations. Future empirical research should test the framework's propositions, and policymakers should consider interventions that bolster the behavioural and social capital dimensions of firm resilience alongside traditional financial support. resilience, theoretical framework, institutional voids, behavioural finance, West Africa, enterprise development This paper introduces a new integrative theoretical model that explicitly links behavioural finance principles with institutional analysis to explain enterprise resilience in Guinea, offering a foundational tool for context-specific research and policy formulation.