Malaria remains a significant public health issue in the Niger Delta region of Nigeria, particularly affecting pregnant women who are at higher risk of severe outcomes. A mixed-methods approach combining survival analysis with qualitative data collection was employed to assess MHCs' efficacy and identify areas for improvement. Mobile health clinics have shown a statistically significant reduction in the incidence of malaria among pregnant women, with an average reduction rate of 25% in morbidity cases over two years. The findings suggest that mobile health clinics play a crucial role in improving maternal and neonatal health outcomes by reducing malaria-related complications. Further expansion of MHCs should be prioritised, with an emphasis on training healthcare providers and ensuring consistent supply chain management to maintain clinic operations.