This article examines Regional Development Disparities in South Sudan: Centre-Periphery Economic Inequalities: Power, Agency, and Structural Change with a focused emphasis on South Sudan within the field of Business. It is structured as a policy analysis article that organises the problem, the strongest verified scholarship, and the main analytical implications in a concise publication-ready format. The paper foregrounds the most relevant institutional, policy, or theoretical dynamics for the African context and closes with a practical conclusion linked to the core argument.