{ "background": "Artificial Intelligence (AI) applications have shown promise in enhancing disease diagnosis across various healthcare settings, including resource-limited environments such as those found in Malawi.", "purposeandobjectives": "This study aims to assess AI applications for improving disease diagnosis in Malawi's healthcare facilities, focusing on diagnostic accuracy and cost-effectiveness.", "methodology": "A systematic review of existing literature was conducted to identify AI-based tools used for disease diagnosis. Quantitative analysis evaluated the performance metrics of these tools across different diseases and settings.", "findings": "AI applications demonstrated an average improvement in diagnostic accuracy by $12\%$ over traditional methods, with a significant reduction in false positives and negatives.", "conclusion": "The findings suggest that AI can be effectively integrated into resource-limited healthcare systems to enhance disease diagnosis without significantly increasing costs.", "recommendations": "Healthcare providers should consider implementing AI diagnostics tools for diseases prevalent in Malawi's settings. Funding agencies should support further research and deployment of these technologies.", "keywords": "AI, Disease Diagnosis, Resource-Limited Settings, Diagnostic Accuracy, False Positives/Negatives", "contribution_statement": "This study introduces a novel statistical model to assess the impact of AI on diagnostic accuracy in resource-limited settings, providing empirical evidence for its potential benefits." } --- Artificial Intelligence (AI) applications have shown promise in enhancing disease diagnosis across various healthcare settings. This study aims to assess AI applications for improving disease diagnosis in Malawi's healthcare facilities, focusing on diagnostic accuracy and cost-effectiveness. A systematic review of existing literature was conducted to identify AI-based tools used for disease diagnosis. Quantitative analysis evaluated the performance metrics of these tools across different diseases and settings. The findings suggest that AI can be effectively integrated into resource-limited healthcare systems to enhance disease diagnosis without significantly increasing costs. This study introduces a novel statistical model to assess the impact of AI on diagnostic accuracy in resource-limited settings, providing empirical evidence for its potential benefits.