This commentary explores comparative business practices in African regions through a Somali lens, focusing on unique regional characteristics and their impact on small businesses. A qualitative approach was employed, drawing on interviews with small business owners and case studies from various regions within Somalia to gather data for analysis. The comparative study highlights the importance of understanding local contexts for effective business strategy formulation in African regions. Recommendations include tailoring business strategies to fit specific regional conditions and advocating for more inclusive policies that address common challenges faced by small businesses across Somalia.