Indigenous Knowledge Systems (IKS) in Seychelles have not been extensively studied within the context of business practices. No empirical data collection was performed for this theoretical framework article; instead, existing literature on IKS and business practices in Seychelles will be synthesized. This theoretical framework provides a foundational understanding of how indigenous knowledge systems can inform business strategy and innovation in Seychelles' unique cultural context. Future research should focus on empirical studies to validate the findings presented here, potentially through surveys or interviews with local small businesses.