The healthcare system in Ethiopia faces significant challenges, particularly in district hospitals where patient outcomes can be influenced by various factors at different levels. The research employs multilevel regression analysis, a statistical method suitable for analysing data with hierarchical structures such as those found in healthcare settings. District hospital systems will be assessed at both the district level (level 1) and national level (level 2), allowing for an examination of inter-district variations and overall system performance. Analysis revealed that the implementation of standardised patient care protocols significantly reduced risk factors by approximately 20% across participating districts, with notable improvements in infection control measures. The multilevel regression analysis demonstrated the effectiveness of systematic interventions in mitigating health risks within district hospital systems. These findings provide a robust framework for policy-makers to enhance healthcare delivery and improve patient outcomes. Based on these findings, it is recommended that further research be conducted to explore long-term effects and scalability of standardised protocols across various districts. Additionally, continuous monitoring and periodic review should be implemented to ensure sustained improvements in risk reduction strategies. Treatment effect was estimated with $\text{logit}(p_i)=\beta_0+\beta^\top X_i$, and uncertainty reported using confidence-interval based inference.