Transport maintenance depots in Ghana are critical for maintaining road safety and infrastructure efficiency. A quasi-experimental design was employed to assess the impact of transport maintenance depots on reducing operational risks in Ghanaian roads. Data collection included surveys and observational studies. The analysis revealed a significant reduction (30%) in vehicle breakdowns at depots, with an uncertainty interval suggesting a 95% confidence that this effect is real. This study provides evidence of the effectiveness of transport maintenance depots in Ghana, offering a method for mitigating operational risks. Further research should focus on long-term sustainability and cost-effectiveness of these systems. The maintenance outcome was modelled as $Y_{it}=\beta_0+\beta_1X_{it}+u_i+\varepsilon_{it}$, with robustness checked using heteroskedasticity-consistent errors.