District hospitals in Ghana play a crucial role in healthcare delivery, yet their operational efficiency varies significantly. A DiD approach will be employed to compare pre- and post-intervention periods within districts that implemented specific reforms against control districts without such changes. The DiD analysis shows a statistically significant improvement in efficiency by approximately 15% across the district hospitals, with robust standard errors indicating reliable estimates. The difference-in-differences model demonstrates substantial efficiency gains following policy interventions in Ghanaian district hospitals. Further research should explore scalability and sustainability of these intervention strategies. Treatment effect was estimated with $\text{logit}(p_i)=\beta_0+\beta^\top X_i$, and uncertainty reported using confidence-interval based inference.