The role of universities in knowledge production and dissemination is crucial within African contexts, particularly in countries like Ghana where higher education institutions play a significant part in shaping educational policies and practices. The study employs a qualitative approach, analysing existing literature and conducting interviews with stakeholders including university administrators, researchers, students, and community members to understand the current landscape of knowledge production and dissemination in Ghanaian universities. Universities in Ghana are actively involved in research projects that address local needs, but there is an uneven distribution of resources across disciplines. For instance, health-related studies receive more funding than those in education or environmental sciences. While universities contribute significantly to knowledge production and dissemination, they face challenges such as resource allocation disparities and limited community engagement, which hinder their full potential in addressing societal needs. To enhance their role, universities should prioritise interdisciplinary research projects that integrate local contexts with global trends. Additionally, fostering stronger partnerships between academic institutions and community organizations could improve the impact of knowledge dissemination.