Indigenous Knowledge Systems (IKS) in Chad's resource economies are underexplored within the context of business practices. A qualitative study employing semi-structured interviews and document analysis among stakeholders including local communities, businesses, and government representatives. The theoretical framework underscores the importance of recognising and integrating IKS into business strategies for effective and equitable development in Chad’s resource sectors. Businesses should collaborate more closely with local communities to leverage their IKS, fostering mutual benefit and sustainable practices.