{ "background": "District hospitals are critical nodes in Kenya's healthcare system, yet systematic evaluations of their operational systems' impact on patient outcomes are scarce. Existing assessments often lack methodological rigour in attributing outcomes to specific systemic interventions.", "purpose and objectives": "This study aimed to quantify the causal effect of a structured hospital systems intervention—comprising standardised triage, laboratory turnaround protocols, and essential drug supply chains—on key clinical outcomes in a Kenyan district hospital setting.", "methodology": "A quasi-experimental, difference-in-differences design was employed. Twelve matched district hospitals were assigned to intervention or control arms. The primary outcome was the composite rate of avoidable clinical deterioration. Data were analysed using a generalised linear mixed model: $logit(P(Y{it}=1)) = \\beta0 + \\beta1(Groupi) + \\beta2(Postt) + \\beta3(Groupi \\times Postt) + \\alpha X{it} + ui + \\epsilon{it}$, where $u_i$ denotes hospital random effects. Robust standard errors were clustered at the hospital level.", "findings": "The intervention was associated with a significant reduction in the composite rate of avoidable clinical deterioration (adjusted odds ratio 0.62, 95% CI 0.48 to 0.79). This equated to an absolute reduction of 7.3 percentage points from a baseline of 18.5% in control hospitals.", "conclusion": "The implemented hospital systems package significantly improved clinical outcomes, demonstrating that structured operational interventions at the district level can enhance care quality.", "recommendations": "Policy should prioritise integrated systems strengthening over single-component inputs. Scaling the intervention requires concurrent investment in health workforce training and routine data systems for monitoring.", "key words": "health systems strengthening, quasi-experimental design, difference-in-differences, clinical outcomes, district hospitals, Kenya", "contribution statement": "This study provides novel,