Electronic prescription systems (EPS) have been increasingly adopted in healthcare settings to improve efficiency and patient safety. A comprehensive literature review was conducted using PubMed, Scopus, and Google Scholar databases. Studies published between and were included for analysis. Among rural healthcare providers in Ethiopia, approximately 45% reported adopting EPS systems, with a notable trend towards increased prescription accuracy and reduced errors compared to manual methods (p < 0.05). Despite initial challenges, the implementation of EPS has shown promise in enhancing medication adherence rates and improving overall health outcomes. Further research should explore long-term effects and potential barriers to wider adoption among rural healthcare providers. Treatment effect was estimated with $\text{logit}(p_i)=\beta_0+\beta^\top X_i$, and uncertainty reported using confidence-interval based inference.