Ghanaian district hospitals face challenges in service delivery and patient safety, necessitating methodological improvements to enhance their effectiveness. A mixed-methods approach combining quantitative data collection through surveys (n=300) and qualitative data from in-depth interviews (n=25), supplemented by observational studies. Randomization was applied to allocate hospitals into intervention or control groups. The randomized field trial revealed a statistically significant reduction ($p < .05$) in patient readmission rates from the intervention group compared to the control group, indicating an effective risk mitigation strategy (92% vs. 81%, CI: -4.63% to -0.27%). The trial demonstrated that targeted interventions can substantially improve hospital performance and patient outcomes. District hospitals should implement the identified risk reduction strategies for improved service delivery and safety.