Theoretical frameworks for comparative business dynamics in Gambian regions are scarce, offering a limited understanding of regional economic activities and their interrelations. Theoretical development will be guided by qualitative and quantitative data analysis, including literature review, expert interviews, and secondary data sources. The theoretical framework identifies distinct yet interconnected patterns of business dynamics, providing a robust foundation for future empirical research on Gambian regions' comparative economic landscapes. Future researchers are encouraged to integrate this framework with regional data to validate its predictive power and applicability across different sectors within Gambian regions.