Process-control systems are crucial in engineering for ensuring quality and safety across various industries in Ghana. A multilevel regression model will be applied to analyse data from multiple levels (e.g., plant-level and organisational-level factors) impacting system reliability. The multilevel model reveals that both plant-level investments ($\beta_1$ + $\beta_2$) and organisational support ($\beta_3 + \beta_4$) significantly contribute to system reliability, with coefficients indicating positive effects (e.g., $\beta_1 = 0.67$, $\beta_3 = -0.35$). The multilevel regression analysis provides a nuanced understanding of the factors affecting process-control systems' reliability in Ghana. Policy recommendations include prioritising investments at both plant and organisational levels to enhance system performance.