The eradication of polio in Northern Nigeria has been a significant public health challenge due to under-immunization and community resistance. A comparative study involving pre- and post-campaign data collection from selected communities across Northern Nigeria, employing quantitative analysis to measure changes in vaccination uptake. Post-campaign vaccination rates increased by 25% among children aged under five years, reflecting a clear positive impact of mobilization efforts on immunization coverage. Community mobilization campaigns significantly improved polio eradication outcomes through enhanced public awareness and active participation in health initiatives. Continue and expand community engagement strategies to sustain high vaccination rates and address remaining challenges such as misinformation and logistical barriers.