Southern Mozambique has historically struggled with low vaccination coverage, leading to persistent public health challenges. The research employs a comparative approach using secondary data from government health records and interviews with key stakeholders. Health facility integration efforts have shown an average increase of 15% in vaccination coverage in the past year, particularly among under-5 age groups. Integration strategies such as improved communication channels and joint immunization campaigns have been effective in enhancing vaccine uptake. Further implementation of these integrated approaches should include targeted training for healthcare workers and enhanced community engagement programmes.