In Johannesburg, South Africa, sex workers are at heightened risk of HIV due to socio-economic factors and service provision practices. A mixed-methods approach combining pre- and post-intervention surveys with qualitative interviews to measure changes in risk-reduction practices among participants. The tailored programmes were effective in promoting safer sex practices among Johannesburg's sex workers, contributing to the broader goal of reducing HIV transmission risks in the community. Sustained support for these prevention efforts is crucial to maintain and build upon observed improvements. Future research should explore long-term sustainability and scalability of such interventions.