Community-based HIV prevention programmes have been implemented in Ugandan urban centers to address high rates of HIV infection among vulnerable populations such as sex workers and their clients. A qualitative approach was employed through semi-structured interviews with programme participants, staff members, and community leaders. Participant observation and document review were also conducted. Programmes in Kampala showed a median duration of three years before ceasing operations, while those in Entebbe lasted an average of four years. Financial sustainability was compromised by funding instability. Despite initial success, most programmes faced challenges related to financial support and community engagement that led to their eventual discontinuation. Investment in long-term planning and securing consistent funding are recommended for the continuation and expansion of successful HIV prevention initiatives.