In Nigeria, district hospitals play a crucial role in providing essential healthcare services to underserved populations. However, their operations and effectiveness are often under-researched. The study employs a mixed-methods approach including both quantitative survey data and qualitative case studies. The primary analytical tool is a linear regression model to estimate the impact of system variables on clinical performance. Analysis revealed significant variability in diagnostic accuracy rates (mean difference = -2.5%, p < 0.05), indicating room for improvement in standard operating procedures. The quasi-experimental design proved effective in identifying key areas needing intervention within the district hospital systems. Immediate attention should be directed towards enhancing diagnostic accuracy and patient care protocols to improve clinical outcomes.