This study examines the methodological assessment of district hospitals in Uganda, focusing on a quasi-experimental design to evaluate cost-effectiveness. A quasi-experimental design was employed, utilising pre- and post-intervention data from multiple districts to measure changes in service delivery metrics such as patient throughput and resource utilization. Significant increases (30%) were observed in outpatient visits per day following the implementation of new operational protocols, with a corresponding decrease (25%) in average waiting times. The quasi-experimental design demonstrated robust results in measuring cost-effectiveness improvements in district hospital systems. These findings suggest that targeted interventions can lead to substantial service enhancements. District health authorities should prioritise the adoption of evidence-based operational protocols for further system-wide improvement and cost savings. Quasi-Experimental Design, District Hospitals, Cost-Effectiveness Analysis, Healthcare Improvement Treatment effect was estimated with $\text{logit}(p_i)=\beta_0+\beta^\top X_i$, and uncertainty reported using confidence-interval based inference.