The healthcare landscape in Uganda, particularly at district hospitals, faces significant challenges that affect service delivery and patient outcomes. A systematic literature review was conducted to identify and analyse existing studies on system reliability in Ugandan district hospitals. The study employed meta-analytic techniques with robust standard errors to estimate the reliability coefficients. The findings indicate a moderate level of system reliability (R = 0.75, CI [0.68-0.82]), suggesting room for improvement but highlighting areas where interventions can be targeted effectively. This study underscores the importance of methodological rigor in assessing healthcare systems and recommends tailored interventions to enhance system performance. District hospitals should prioritise systematic reviews to identify critical areas needing improvement, and implement evidence-based strategies based on reliability measurements. Panel Data Analysis, System Reliability, Healthcare Systems, District Hospitals, Uganda