This article examines Anti-Corruption Agencies in East Africa: Independence, Effectiveness, and Political Interference: Multi-Level Governance Perspectives with a focused emphasis on Ghana within the field of Political Science. It is structured as a action research study that organises the problem, the strongest verified scholarship, and the main analytical implications in a concise publication-ready format. The paper foregrounds the most relevant institutional, policy, or theoretical dynamics for the African context and closes with a practical conclusion linked to the core argument.