Urban youth in Cairo, Egypt face significant challenges related to HIV/AIDS prevention. High rates of infection among this demographic underscore the need for effective intervention strategies. A mixed-methods approach was employed, combining qualitative interviews with structured surveys to gather data from a representative sample of urban youth (n=500) across various socio-economic backgrounds. Urban youth in Cairo showed moderate adoption rates for established prevention programmes (42%), with notable disparities observed between different socioeconomic groups. The most effective strategy employed was peer-led education, which yielded the highest perceived efficacy among surveyed participants (65%). The reviewed urban youth HIV/AIDS prevention strategies exhibited variability across social strata and were generally well-received by those who adopted them. Further research should focus on enhancing peer-led educational programmes and addressing socio-economic disparities to improve overall adoption rates and efficacy.