Psychological assessment tools are essential for understanding mental health in diverse populations, including African adolescents. However, these tools often need to be adapted to suit local cultural contexts. A mixed-methods approach was employed, including qualitative interviews with experts, quantitative data collection from a representative sample of adolescents in Tunisia, and statistical analyses to assess the validity and reliability of adapted tools. The adaptation process revealed significant cultural nuances affecting tool performance; for instance, some items were found to have ambiguous translations or cultural relevance issues that compromised their utility across different contexts. Our findings highlight the importance of thorough cross-cultural adaptations when using psychological assessment tools in Tunisia and suggest modifications needed for future research and clinical applications. We recommend rigorous pre-testing, ongoing validation studies, and culturally sensitive training for practitioners implementing these adapted tools to ensure their effectiveness and reliability. Psychological Assessment Tools, Cross-Cultural Adaptation, Tunisian Adolescents, Psychological Health