Tuberculosis (TB) remains a significant public health issue in Sub-Saharan Africa, with varying treatment protocols across different countries. A comparative study using data from healthcare records of TB patients in both countries, focusing on dosing protocols and treatment outcomes. Senegalese patients showed a higher success rate with the standardised anti-TB drug protocol compared to Kenyan counterparts (52% vs. 40%, p < 0.05). The study highlights the need for tailored anti-TB protocols in Senegal, which could potentially improve treatment outcomes. Further research should be conducted to validate these findings and explore potential interventions.