Entrepreneurship ecosystems and innovation hubs have become critical components in contemporary economic development strategies across various regions. This study employs a qualitative comparative analysis approach to synthesize existing literature on entrepreneurship ecosystems and innovation hubs in East Africa. The theoretical framework provides a robust foundation for policymakers and practitioners aiming to enhance entrepreneurship support in Nigeria by drawing lessons from successful models in East Africa. Based on the insights derived, recommendations are proposed for fostering a vibrant entrepreneurial ecosystem that aligns with Nigerian socio-economic needs.