Entrepreneurship ecosystems in Tanzania have shown promise but require further theoretical exploration to understand their dynamics and impact on innovation hubs. No empirical data are included; rather, the article synthesizes existing literature on entrepreneurship ecosystems and innovation hubs from East Africa, focusing on Tanzania's unique context. The theoretical framework proposed will serve as a foundational resource for researchers and policymakers aiming to enhance entrepreneurship ecosystems in Tanzania. Future research should focus on developing targeted interventions based on the insights gained from this theoretical framework, particularly in areas like digital financing and capacity building for entrepreneurs.