Mobile health clinics have been introduced in urban Ghana to provide accessible healthcare services, including vaccinations and preventive care for primary school children. A mixed-methods approach was employed, involving both quantitative surveys assessing knowledge and attitudes (n=120) and qualitative interviews exploring perceptions and experiences (n=15). The survey revealed a significant increase in the proportion of children who reported practicing good hygiene habits after clinic visits, with 75% compared to 60% before. Mobile health clinics appear effective in changing behaviour regarding hygiene practices among primary school children in urban Ghana. Further research is recommended to explore other behaviors and long-term impacts. Communities should be engaged for sustained support of these clinics, with a focus on reinforcing hygiene education beyond clinic visits. Mobile Health Clinics, Primary School Children, Behaviour Change, Urban Ghana