Côte d'Ivoire is a significant producer of fruits and vegetables in West Africa, yet post-harvest losses remain substantial, contributing to economic inefficiencies and food security challenges. A mixed-methods approach will be employed, incorporating literature reviews, expert interviews, and scenario analyses to identify key factors affecting post-harvest loss reduction. The theoretical framework outlines strategies for policymakers and stakeholders to address post-harvest loss issues through targeted interventions such as improved storage facilities and enhanced supply chain management. Policymakers should prioritise the development and implementation of the proposed infrastructure solutions, coupled with capacity-building programmes for farmers and extension services. The empirical specification follows $Y=\beta_0+\beta^\top X+\varepsilon$, and inference is reported with uncertainty-aware statistical criteria.