This case study examines the critical pathway from academic business research to tangible policy reform in Ghana between 2010 and 2024. It addresses the problem of how locally generated scholarship can effectively inform national economic and governance strategies, a process vital for Africa’s self-determined development. Employing a rigorous qualitative methodology, the analysis triangulates data from key policy documents—such as the Ghana Industrial Policy and the National Entrepreneurship and Innovation Plan—with influential research outputs from Ghanaian academic institutions. The study establishes that a discernible, albeit inconsistent, channel of influence exists. Findings indicate that research on small and medium enterprise financing, digital entrepreneurship, and informal sector formalisation has demonstrably shaped policy rhetoric and specific programme designs, particularly from 2015 onwards. However, the translation of these influences into sustained implementation and scaled impact remains fragmented. The significance of this work lies in its empirical contribution to African scholarship on evidence-based policymaking, highlighting the agency of local academics. It concludes that strengthening institutionalised partnerships between universities, think tanks, and government ministries is imperative for Ghana, and similar nations, to systematically harness indigenous research for more effective and contextually relevant economic governance.