Comparative education studies in African regions have highlighted significant disparities in educational practices across different countries and regions. This comparative study employed a mixed-methods approach involving surveys, interviews with educators, and observational assessments of classrooms. Data were collected from two Ugandan regions: Region A and Region B, using standardised tools to ensure comparability. The findings indicate that while both regions have adopted national curricula, there are notable variations in the implementation strategies used by teachers. For instance, Region A has seen a higher proportion (35%) of teachers implementing blended learning methods compared to Region B (20%). This study concludes that regional differences significantly influence educational practices and outcomes. Based on these findings, recommendations are made for policy makers to consider the unique contexts when designing national curricula and professional development programmes tailored to specific regions in Uganda. Comparative Education, Ugandan Regions, Educational Practices, Student Outcomes