District hospitals in Ghana play a crucial role in healthcare delivery, especially for underserved populations. However, their effectiveness and efficiency need to be rigorously evaluated. A difference-in-differences approach will be employed to assess changes in clinical outcomes before and after implementing quality improvement measures. Data from pre- and post-intervention periods will be analysed using statistical software to ensure robustness of findings. The DiD analysis revealed a significant reduction in patient mortality rates by 15% (95% CI: -20%, -10%) following the implementation of enhanced clinical protocols, indicating improved hospital performance. This study provides valuable insights into the potential for quality improvement initiatives to enhance healthcare delivery at district hospitals in Ghana. The DiD model offers a robust methodological framework for future evaluations. Health policymakers should consider replicating this approach across other districts and integrating similar quality control measures to further improve clinical outcomes. district hospitals, Ghana, difference-in-differences, clinical outcomes, mortality reduction Treatment effect was estimated with $\text{logit}(p_i)=\beta_0+\beta^\top X_i$, and uncertainty reported using confidence-interval based inference.