Non-invasive prenatal screening (NIPS) is a method used to detect certain genetic conditions in fetuses without invasive procedures. A review of hospital records was conducted, focusing on patient demographics and screening results. The proportion of women opting for NIPS increased from 35% to 48% over the study period. NIPS has become more widely accepted in South African hospitals, with a notable increase in uptake. Further education programmes on NIPS benefits should be implemented to enhance acceptance and utilization. Treatment effect was estimated with $\text{logit}(p_i)=\beta_0+\beta^\top X_i$, and uncertainty reported using confidence-interval based inference.