Community health centres in Kenya are crucial for primary healthcare services. However, their effectiveness and cost-effectiveness have not been systematically evaluated. A mixed-methods approach was employed, incorporating both quantitative data collection through surveys and qualitative insights from interviews. The study used a quasi-experimental design to compare pre- and post-intervention outcomes across different health centres in Kenya. There was an observed increase of 15% in patient compliance rates following the implementation of new healthcare protocols, which is statistically significant at the $p < 0.05$ level. The quasi-experimental design provided robust evidence for cost-effectiveness improvements in community health centre systems in Kenya. Future studies should consider a larger sample size and longitudinal data to further validate these findings and explore broader implications. Community Health Centres, Quasi-Experimental Design, Cost-Effectiveness Assessment, Healthcare Systems