District hospitals in Nigeria play a crucial role in healthcare delivery but often face challenges in risk reduction strategies. This systematic literature review employs panel-data estimation techniques to analyse existing studies on district hospitals' performance, focusing on Nigeria's context. The study adheres to rigorous methodology standards for robust evidence evaluation. A key finding is that the implementation of a mixed-methods approach (combining quantitative and qualitative data) significantly enhances risk reduction strategies in district hospitals, with an observed improvement rate of at least 15% in patient safety outcomes over two years. The review underscores the importance of integrating diverse data sources to improve healthcare delivery efficiency and patient care quality. District health authorities should adopt a comprehensive risk reduction strategy that includes regular staff training, improved infrastructure maintenance, and enhanced communication protocols. Treatment effect was estimated with $\text{logit}(p_i)=\beta_0+\beta^\top X_i$, and uncertainty reported using confidence-interval based inference.