Title: Policy Implications of Medical Research in Africa: A South African Perspective Medical research in Africa has expanded, but its translation into effective health policy remains inconsistent. South Africa produces a substantial portion of the continent’s research output yet continues to face challenges in health equity and system performance, highlighting a persistent research-policy gap. This brief report analyses the policy implications of medical research conducted in South Africa for the broader African context. It aims to identify the principal barriers and enablers influencing the uptake of research into health policy and practice. A narrative synthesis was conducted. This involved a critical review of relevant policy documents, institutional reports, and existing literature on research translation within the South African health sector. A dominant theme was the disconnect between research priorities and health system needs. A significant proportion of identified barriers related to systemic issues, including weak institutional linkages between researchers and policymakers and limited dedicated funding for implementation science. The translation of medical research into health policy in South Africa is hindered primarily by systemic and structural factors, not merely a lack of scientific evidence. This undermines the potential impact of research on health outcomes. Establish formal, funded knowledge translation platforms within health ministries. Prioritise funding for implementation research co-designed with policymakers. Strengthen capacity for health policy analysis within research institutions. Knowledge translation, health policy, research utilisation, South Africa, implementation science This report synthesises critical perspectives on the research-policy gap in a leading African research hub, offering pragmatic recommendations for systemic change.