This study addresses a current research gap in Medicine concerning Prevalence and clinical significance of BRCA1/2 mutations and large genomic rearrangements in high-risk breast cancer families in Tunisia in Tunisia. The objective is to clarify key debates, identify practical implications, and outline a focused agenda for scholarship and policy. A qualitative approach was used, drawing on recent literature and policy sources to frame the analysis. This abstract is primarily indicative, outlining the scope and conceptual framing rather than reporting empirical results. The paper argues for context‑specific approaches and stronger empirical foundations in future research. Recommendations are not applicable for this abstract type. Prevalence and clinical significance of BRCA1/2 mutations and large genomic rearrangements in high-risk breast cancer families in Tunisia, Tunisia, Africa, Medicine, perspective This structured abstract provides a standardised summary to support rapid screening, indexing, and assessment of scholarly contribution.