Comparative Renal and Metabolic Outcomes of Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide in Older South African Adults Living with HIV: A Systematic Review

This study addresses a current research gap in Medicine concerning The long-term renal and metabolic effects of tenofovir disoproxil fumarate versus tenofovir alafenamide in a cohort of older persons with HIV in South Africa in South Africa. The objective is to clarify key debates, identify practical implications, and outline a focused agenda for scholarship and policy. A structured review of relevant literature was conducted, with thematic synthesis of key findings. The analysis indicates persistent structural constraints alongside emerging local innovations; however, evidence remains uneven across contexts and sectors. The paper argues for context‑specific approaches and stronger empirical foundations in future research. Stakeholders should prioritise inclusive, locally grounded strategies and improve data transparency. The long-term renal and metabolic effects of tenofovir disoproxil fumarate versus tenofovir alafenamide in a cohort of older persons with HIV in South Africa, South Africa, Africa, Medicine, review article This structured abstract provides a standardised summary to support rapid screening, indexing, and assessment of scholarly contribution.