Zoonotic diseases pose significant public health risks in Ethiopia's northern abattoirs, where animal-to-human transmission occurs through contaminated meat products. A mixed-methods approach combining quantitative analysis of disease prevalence and qualitative interviews with abattoir workers to identify potential control measures. An alarming $p = 0.01$ significance level indicated a high risk of E.coli O157 transmission, which was confirmed in 32% of sampled meat products. The surveillance programme highlighted the need for stricter hygiene protocols and improved waste management practices to mitigate zoonotic disease risks in abattoirs. Implementing rigorous food safety training programmes and upgrading sanitation facilities are recommended interventions to reduce the incidence of zoonotic diseases. Zoonotic Diseases, Abattoir Surveillance, Risk Assessment, Intervention Analysis