Community health centers in Senegal face challenges in maintaining system reliability due to various factors such as funding, staff training, and operational inefficiencies. A comprehensive search strategy was employed across relevant databases including PubMed and Scopus. Studies were selected based on predefined inclusion criteria such as use of difference-in-differences (DID) models to assess system reliability over time. Methodological quality was evaluated using established frameworks like the Cochrane Risk of Bias tool. The review identified a consistent trend where DID models effectively demonstrated changes in health outcomes attributable to system interventions, with some studies reporting statistically significant improvements in vaccination coverage by 12% (95% CI: 8%, 16%). DID models provide robust evidence for understanding the impact of community health centre systems on health outcomes, offering a reliable methodological approach. Given the positive findings from DID models, there is merit in scaling up similar interventions with ongoing monitoring and evaluation to ensure sustained system reliability. Senegal, Community Health Centers, Difference-in-Differences, System Reliability, Methodological Evaluation Treatment effect was estimated with $\text{logit}(p_i)=\beta_0+\beta^\top X_i$, and uncertainty reported using confidence-interval based inference.