Adolescent girls in Senegal face high risks of HIV infection due to socio-economic factors such as early marriage and educational barriers. A mixed-methods approach combining quantitative surveys with qualitative interviews to evaluate programme effectiveness over a two-year period. Engagement rates reached up to 85% at the end of the second year for those receiving comprehensive HIV education, compared to 60% in control groups. Comprehensive school-based HIV prevention programmes significantly increased engagement and knowledge retention among adolescent girls in Senegal over two years. Continuation and expansion of such programmes are recommended alongside continued monitoring and evaluation for sustained impact. HIV Prevention, Adolescent Girls, School-Based Programmes, Engagement Rates, Senegal