This review examines compliance rates of Ghanaian retail food businesses with South Sudanese food safety standards. A mixed-methods approach was employed, including surveys of businesses and case studies in selected regions. Compliance rates varied significantly, with urban areas showing higher adherence (70%) compared to rural settings (35%). Rural businesses often lacked necessary infrastructure and training, highlighting the need for targeted interventions. Policy-makers should prioritise capacity building programmes in underserved regions to improve compliance rates.