Youth activism in Guinea-Bissau's business landscape is a growing phenomenon that reflects broader socio-economic challenges and opportunities. Qualitative research methods were employed through interviews with young entrepreneurs and focus group discussions among relevant stakeholders. Youth-led initiatives have contributed significantly to innovative business models that address local needs, particularly in the agricultural sector (30% of youth-led enterprises). The findings highlight the potential for youth entrepreneurship as a catalyst for sustainable economic development and innovation in Guinea-Bissau. Policy makers are encouraged to implement measures supporting young entrepreneurs' access to resources, training, and market opportunities.