Community health centres in South Africa have faced challenges in cost-effectiveness due to varying operational models. A systematic literature review was conducted using quantitative methods, focusing on empirical studies from to . Panel-data techniques were applied to analyse cost-efficiency metrics across different regions in South Africa. The analysis revealed that while some health centres showed significant cost savings (proportion >5%), others had inefficiencies with costs exceeding the allocated budget by over 10%. Variability in operational models significantly influenced these outcomes. Despite methodological challenges, panel-data methods provided insights into the cost-effectiveness of community health centre systems, highlighting areas for improvement and better resource allocation strategies. Further research should focus on longitudinal studies to understand long-term impacts and implement standardised operational models across all regions. Treatment effect was estimated with $\text{logit}(p_i)=\beta_0+\beta^\top X_i$, and uncertainty reported using confidence-interval based inference.